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Curriculum Vitae for Sherif S. Morgan Education:
Cancer Biology PhD Candidate, University of Arizona, Tucson, AZ
August 2004 to Present. Overall GPA: 3.91.
BS in Molecular and Cellular Biology, May 2002. University of Arizona, Tucson, Arizona.
Honors & Summa Cum Laude with a major GPA of 4.0 and overall GPA of 3.975 on a 4.0 scale.
Senior Honors Thesis: Applications of Wildtype and Mutant Luciferase: Monitoring Metastasis In Vivo.
Research Experience:
Cancer Biology Graduate Program, University of Arizona, Tucson, AZ
Advisor: Emmanuelle Meuillet. May 2005 to present. Investigate the role of the bile acid, deoxycholic acid, in colorectal cancer promotion via the insulin-like growth factor-I receptor.
Research Technician, University of Arizona, Tucson, AZ, Dr. Donato Romagnolo Lab, July 2002 to August 2004. Molecular biology techniques were utilized to investigate the pathways that regulate transcription of the tumor suppressor, BRCA1.
Summary of Undergraduate Research, University of Arizona, January 2000 to May 2002: Senior Honors Thesis, University of Arizona, Dr. Robert Gillies Lab, 08/01 – 05/02.
Compared the effectiveness of wildtype and mutant luciferase as reporter genes to monitor tumor metastasis in vivo.
Undergraduate Biology Research Program, University of Arizona, Dr. Gillies Lab, 05/01 – 08/01.
Characterized the kinetics of the wildtype and mutant luciferase bioluminescent reaction through in vitro half-life studies.
Undergraduate Biology Research Program, University of Arizona, Dr. Gillies Lab, 05/00 – 04/01.
Identified and characterized the altered enzymatic steps in the biochemical pathway of phosphomonoester metabolism that lead to the elevation of phosphocholine in breast cancer.
Publications:
Sherif S. Morgan, Samira Jean-Louis, and Emmanuelle J. Meuillet. Deoxycholic acid modulates the insulin-like growth factor-I receptor in colorectal cancer cells. (Planned).
Shawna Comer, Zuohe Song, Samira Jean-Louis, Margareta Berggren, Sherif S. Morgan, Benjamin George, and Emmanuelle J. Meuillet. Deoxycholic Acid Downregulates EphB2 Expression in Human Colorectal Cancer Cells: Protective Role of Cholecalciferol. (will be submitted to Carcinogenesis soon).
Samira Jean-Louis, Sherif S. Morgan, Bernard Guerold, Gerard Cremel, and Emmanuelle J. Meuillet. DCA-induced Signaling is mediated through the modulation of glycosphingolipids. Submitted to the Journal of Biological Chemistry.
Hockings JK, Thorne PA, Kemp MQ, Morgan SS, Selmin O, Romagnolo DF. The ligand status of the aromatic hydrocarbon receptor modulates transcriptional activation of BRCA-1 promoter by estrogen. Cancer Research. 2006 Feb 15; 66(4):2224-32.
Jeffy BD, Hockings JK, Kemp MQ, Morgan SS, Hager JA, Beliakoff J, Whitesell LJ, Bowden GT, Romagnolo DF. An Estrogen Receptor-alpha/p300 Complex Activates the BRCA-1 Promoter at an AP-1 Site That Binds Jun/Fos Transcription Factors: Repressive Effects of p53 on BRCA-1 Transcription. Neoplasia. 2005 Sep; 7(9):873-82.
Baggett B, Roy R, Momen S, Morgan S, Tisi L, Morse D, Gillies RJ. Thermostability of firefly luciferases affects efficiency of detection by in vivo bioluminescence. Molecular Imaging. 2004 Oct; 3(4):324-32.
Posters and Abstracts: Deoxycholic acid (DCA)-induced signaling in colorectal cancer via the insulin-like growth factor I receptor (IGF-IR). Keystone Symposia: Molecular Targets for Chemoprevention meeting on March 6-10, 2006.
Regulation of the PI3K-Akt Pathway: Nutritional Modulation of Colorectal Cancer. Frontiers in Nutritional Sciences, University of Arizona. October 20-21, 2005.
Requirement of the estrogen receptor-alpha and aromatic hydrocarbon receptor in transcriptional regulation of BRCA-1. Presented by Chi-Fan (Jennifer) Ku Hockings at the AACR, April 2005.
D. Morse, D. Carroll, S. Morgan, B. Baggett, R. J. Gillies (2002) Gene expression profiling of choline metabolism in human breast cancer cells. Proc. Intl. Soc. Mag. Reson. Med 11: 1310.
Leadership and Awards:
- Cancer Biology Graduate Interdisciplinary Program Student Representative. May 2007 to Present.
- Scientific Facilitator of the 2007 Exploring the Entrepreneurial Dimensions of Science and Technology Workshop at the McGuire Center for Entrepreneurship at the University of Arizona. April 2007.
- Cancer Biology Pre-Doctoral Training Grant (NIH T32 CA09213) – September 2004 to August 2005
- Previous Memberships: Phi Beta Kappa, Phi Kappa Phi, Golden Key National Honor Societies
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